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Palladium-Catalyzed Synthesis of Phthalazinones: Efficient Carbonylative Coupling of 2-Bromobenzaldehydes and Hydrazines

Authors

  • Dr. Xiao-Feng Wu,

    Corresponding author
    1. Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, Zhejiang Province, 310018 (P.R. China)
    2. Leibniz-Institut für Katalyse e.V. an der Universitüt Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
    • Department of Chemistry, Zhejiang Sci-Tech University, Xiasha Campus, Hangzhou, Zhejiang Province, 310018 (P.R. China)
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  • Dr. Helfried Neumann,

    1. Leibniz-Institut für Katalyse e.V. an der Universitüt Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
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  • Stephan Neumann,

    1. Leibniz-Institut für Katalyse e.V. an der Universitüt Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
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  • Prof. Dr. Matthias Beller

    Corresponding author
    1. Leibniz-Institut für Katalyse e.V. an der Universitüt Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
    • Leibniz-Institut für Katalyse e.V. an der Universitüt Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
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Abstract

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Phthalazinones made easy! A new, straightforward methodology for the carbonylative synthesis of phthalazinones has been established. Starting from readily available 2-bromobenzaldehydes or 2-bromoacetophenone and hydrazines, a variety of phthalazinones have been produced in good isolated yields (see scheme).

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