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Polychromatic Decoupling of a Manifold of Homonuclear Scalar Interactions in Solution-State NMR

Authors

  • Dr. Diego Carnevale,

    Corresponding author
    1. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, BCH,1015 Lausanne (Switzerland), Fax: (+41) 21-693-94-35
    • Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, BCH,1015 Lausanne (Switzerland), Fax: (+41) 21-693-94-35
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  • Takuya F. Segawa,

    1. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, BCH,1015 Lausanne (Switzerland), Fax: (+41) 21-693-94-35
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  • Prof. Geoffrey Bodenhausen

    1. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, BCH,1015 Lausanne (Switzerland), Fax: (+41) 21-693-94-35
    2. Département de Chimie, Ecole Normale Supérieure, 24 Rue Lhomond, 75231, Paris Cedex 05 (France)
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Abstract

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Window-acquired tetrachromatic irradiation allows one to decouple simultaneously four amide protons in cyclosporine A (wavy arrows; see figure) leading to simplified multiplets of the alpha protons. By inserting a manifold of polychromatic pulses in each dwell time, several subsystems can be decoupled simultaneously.

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