Copper-Catalyzed Synthesis of Quinazolines in Water Starting from o-Bromobenzylbromides and Benzamidines

Authors

  • Dr. Chandi C. Malakar,

    1. Institut für Chemie, Universität Hohenheim, Garbenstr. 30, 70599 Stuttgart (Deutschland), Fax: (+) (49) 711-459-22951
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  • Dr. Alevtina Baskakova,

    1. Institut für Chemie, Universität Hohenheim, Garbenstr. 30, 70599 Stuttgart (Deutschland), Fax: (+) (49) 711-459-22951
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  • Dr. Jürgen Conrad,

    1. Institut für Chemie, Universität Hohenheim, Garbenstr. 30, 70599 Stuttgart (Deutschland), Fax: (+) (49) 711-459-22951
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  • Prof. Dr. Uwe Beifuss

    Corresponding author
    1. Institut für Chemie, Universität Hohenheim, Garbenstr. 30, 70599 Stuttgart (Deutschland), Fax: (+) (49) 711-459-22951
    • Institut für Chemie, Universität Hohenheim, Garbenstr. 30, 70599 Stuttgart (Deutschland), Fax: (+) (49) 711-459-22951
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Abstract

original image

Water makes it possible: The Cu2O-catalyzed reaction between easily available o-bromobenzylbromides and benzamidines by using Cs2CO3 as the base and N,N′-dimethylethylenediamine (DMEDA) as the additive in water as the solvent gives access to substituted quinazolines in a single step with yields ranging from 57 to 85 % (see scheme).

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