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Zinc-Catalyzed Dehydrogenative N-Silylation of Indoles with Hydrosilanes

Authors

  • Prof. Dr. Teruhisa Tsuchimoto,

    Corresponding author
    1. Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571 (Japan), Fax: (+81) 44-934-7228
    • Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571 (Japan), Fax: (+81) 44-934-7228
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  • Yoshihiko Iketani,

    1. Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571 (Japan), Fax: (+81) 44-934-7228
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  • Masaru Sekine

    1. Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571 (Japan), Fax: (+81) 44-934-7228
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Abstract

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Zinc catalysis: Zinc triflate in a nitrile solvent behaved as an effective catalyst for dehydrogenative N-silylation with a variety of indoles and hydrosilanes (see scheme). The addition of pyridine greatly accelerated the N-silylation reaction to produce N-silylindoles exclusively in high to excellent yields.

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