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Keywords:

  • C[BOND]H activation;
  • continuous-flow reactions;
  • copper;
  • ethers;
  • oxidative coupling
Thumbnail image of graphical abstract

Peroxides and ethers in flow: 2-Carbonyl-substituted phenols and β-ketoesters react safely with ethers in a microreactor environment using a copper catalyst and an organic peroxide (TBHP). This protocol results in unsymmetrical acetal scaffolds not easily available otherwise (see scheme).