Communication

Copper-Catalyzed Formation of C[BOND]O Bonds by Direct α-C[BOND]H Bond Activation of Ethers Using Stoichiometric Amounts of Peroxide in Batch and Continuous-Flow Formats

  1. G. Sathish Kumar1,
  2. Bartholomäus Pieber2,
  3. Dr. K. Rajender Reddy1,*,
  4. Prof. Dr. C. Oliver Kappe2,*

Article first published online: 11 APR 2012

DOI: 10.1002/chem.201200815

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 18, Issue 20, pages 6124–6128, May 14, 2012

Additional Information

How to Cite

Kumar, G. S., Pieber, B., Reddy, K. R. and Kappe, C. O. (2012), Copper-Catalyzed Formation of C[BOND]O Bonds by Direct α-C[BOND]H Bond Activation of Ethers Using Stoichiometric Amounts of Peroxide in Batch and Continuous-Flow Formats. Chem. Eur. J., 18: 6124–6128. doi: 10.1002/chem.201200815

Author Information

  1. 1

    Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 607 (India), Fax: (+91) 40-27160921

  2. 2

    Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840

*Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 607 (India), Fax: (+91) 40-27160921

Publication History

  1. Issue published online: 3 MAY 2012
  2. Article first published online: 11 APR 2012
  3. Manuscript Received: 10 MAR 2012

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (286K)

Keywords:

  • C[BOND]H activation;
  • continuous-flow reactions;
  • copper;
  • ethers;
  • oxidative coupling
Thumbnail image of graphical abstract

Peroxides and ethers in flow: 2-Carbonyl-substituted phenols and β-ketoesters react safely with ethers in a microreactor environment using a copper catalyst and an organic peroxide (TBHP). This protocol results in unsymmetrical acetal scaffolds not easily available otherwise (see scheme).

View Full Article with Supporting Information (HTML) Get PDF (286K)