Copper-Catalyzed Formation of C[BOND]O Bonds by Direct α-C[BOND]H Bond Activation of Ethers Using Stoichiometric Amounts of Peroxide in Batch and Continuous-Flow Formats

Authors

  • G. Sathish Kumar,

    1. Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 607 (India), Fax: (+91) 40-27160921
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  • Bartholomäus Pieber,

    1. Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840
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  • Dr. K. Rajender Reddy,

    Corresponding author
    1. Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 607 (India), Fax: (+91) 40-27160921
    • Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Tarnaka, Hyderabad-500 607 (India), Fax: (+91) 40-27160921
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  • Prof. Dr. C. Oliver Kappe

    Corresponding author
    1. Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840
    • Christian Doppler Laboratory for Microwave Chemistry (CDLMC) and Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, 8010 Graz (Austria), Fax: (+43) 316-380-9840
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Abstract

original image

Peroxides and ethers in flow: 2-Carbonyl-substituted phenols and β-ketoesters react safely with ethers in a microreactor environment using a copper catalyst and an organic peroxide (TBHP). This protocol results in unsymmetrical acetal scaffolds not easily available otherwise (see scheme).

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