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Rhodium-Catalyzed Linear Cross-Trimerization of Two Different Alkynes with an Alkene and Two Different Alkenes with an Alkyne



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Crossing paths with rhodium: A cationic RhI/H8-BINAP complex has been found to catalyze the linear cross-trimerization of terminal alkynes, acetylenedicarboxylates, and acrylamides to give substituted trienes. The asymmetric linear cross-trimerization, giving substituted chiral dienes, has also been achieved by using monosubstituted alkenes and (R)-BINAP instead of terminal alkynes and H8-BINAP (see scheme; H8-BINAP=2,2′-bis(diphenylphosphino)-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl; BINAP=2,2′-bis(diphenylphosphino)-1,1′-binaphthyl]).