Fast, efficient and green! Highly regioselective and efficient catalyst- and halogen-free Friedel–Crafts α-ketoacylation reactions leading to heterocycles functionalized with a very versatile 1,3-diketone moiety are described. The reactions rely on microwave-assisted domino Wolff rearrangement/Friedel–Crafts sequences from 2-diazo-1,3-diketones via transient, highly reactive α-keto ketene intermediates.
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