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Enhanced Red Emission from GdF3:Yb3+,Er3+ Upconversion Nanocrystals by Li+ Doping and Their Application for Bioimaging

Authors

  • Wenyan Yin,

    1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
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  • Dr. Lina Zhao,

    1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
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  • Liangjun Zhou ,

    1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
    2. College of Materials Science and Opto-Electronic Technology, Graduate University of Chinese Academy of Sciences, Beijing 100049 (P. R. China)
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  • Dr. Zhanjun Gu,

    Corresponding author
    1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
    • Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
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  • Xiaoxiao Liu,

    1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
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  • Gan Tian ,

    1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
    2. College of Chemistry, Sichuan University, Chengdu, 610064 (P. R. China)
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  • Shan Jin ,

    1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
    2. College of Materials Science and Opto-Electronic Technology, Graduate University of Chinese Academy of Sciences, Beijing 100049 (P. R. China)
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  • Liang Yan,

    1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
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  • Wenlu Ren,

    1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
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  • Prof. Gengmei Xing,

    1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
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  • Prof. Yuliang Zhao 

    Corresponding author
    1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
    2. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanosciences and Technology of China, Beijing, 100190 (P. R. China)
    • Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (P. R. China), Fax: (+86) 10-88236786
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Abstract

Under 980 nm near-infrared (NIR) excitation, upconversion luminescent (UCL) emission of GdF3:Yb,Er upconversion nanoparticles (UCNPs) synthesized by a simple and green hydrothermal process can be tuned from yellow to red by varying the concentration of dopant Li+ ions. A possible mechanism for enhanced red upconverted radiation is proposed. A layer of silica was coated onto the surface of GdF3:Yb,Er,Li UCNPs to improve their biocompatibility. The silica-coated GdF3:Yb,Er,Li UCNPs show great advantages in cell labeling and in vivo optical imaging. Moreover, GdF3 UCNPs also exhibited a positive contrast effect in T1-weighted magnetic resonance imaging (MRI). These results suggest that the GdF3 UCNPs could act as dual-modality biolabels for optical imaging and MRI.

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