Cucurbit[7]uril Pseudorotaxane-Based Photoresponsive Supramolecular Nanovalve

Authors

  • Yu-Long Sun,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, Jilin 130012 (P.R. China)
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  • Dr. Bing-Jie Yang,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, Jilin 130012 (P.R. China)
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  • Dr. Sean Xiao-An Zhang,

    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, Jilin 130012 (P.R. China)
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  • Prof. Ying-Wei Yang

    Corresponding author
    1. State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, Jilin 130012 (P.R. China)
    • State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, Jilin 130012 (P.R. China)
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Abstract

original image

Light relief! Mesoporous silica materials equipped with photoresponsive cucurbit[7]uril-pseudorotaxane nanovalves operate in biological media to trap cargo molecules within nanopores, but undergo controlled release when irradiated with light of a suitable wavelength (see figure). Significantly, a “ladder”-release pattern is obtained to balance maximal therapeutic efficacy and minimal dose frequency in the development of “pulsed” drug therapy.

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