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Keywords:

  • drug delivery;
  • host–guest systems;
  • macrocyclic receptors;
  • mesoporous materials;
  • supramolecular chemistry
Thumbnail image of graphical abstract

Light relief! Mesoporous silica materials equipped with photoresponsive cucurbit[7]uril-pseudorotaxane nanovalves operate in biological media to trap cargo molecules within nanopores, but undergo controlled release when irradiated with light of a suitable wavelength (see figure). Significantly, a “ladder”-release pattern is obtained to balance maximal therapeutic efficacy and minimal dose frequency in the development of “pulsed” drug therapy.