Communication

An Acid-Catalyzed Cyclialkylation that Provides Rapid Access to a Twisted Molecular Basket

  1. Keith Hermann,
  2. Daniel A. Turner,
  3. Prof. Christopher M. Hadad,
  4. Prof. Jovica D. Badjić*

Article first published online: 4 JUN 2012

DOI: 10.1002/chem.201201153

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 18, Issue 27, pages 8301–8305, July 2, 2012

Additional Information

How to Cite

Hermann, K., Turner, D. A., Hadad, C. M. and Badjić, J. D. (2012), An Acid-Catalyzed Cyclialkylation that Provides Rapid Access to a Twisted Molecular Basket. Chem. Eur. J., 18: 8301–8305. doi: 10.1002/chem.201201153

Author Information

  1. Department of Chemistry and Biochemistry, The Ohio State University, 100 West 18thAvenue, Columbus OH 43210 (USA), Fax: (+) 614-292-1685

*Department of Chemistry and Biochemistry, The Ohio State University, 100 West 18thAvenue, Columbus OH 43210 (USA), Fax: (+) 614-292-1685

Publication History

  1. Issue published online: 22 JUN 2012
  2. Article first published online: 4 JUN 2012
  3. Manuscript Received: 4 APR 2012

Funded by

  • National Science Foundation
  • CHE-1012146
  • Defense Threat Reduction Agency. Grant Number: HDTRA1–11–1–0042
  • Ohio Supercomputer Center

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Keywords:

  • carbenium ions;
  • cavitands;
  • chirality;
  • host–guest chemistry;
  • kinetics
Thumbnail image of graphical abstract

Twist of fate: Expanding the scope of cavity-containing compounds is essential for developing more efficient sensors and catalysts. This report describes an efficient cyclialkylation reaction that provides rapid access to a novel C3 symmetric and chiral cavitand (see figure). The host can be prepared in larger quantities through two synthetic steps and from simple starting materials.

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