Communication

Direct Amidation of Alcohols with N-Substituted Formamides under Transition-Metal-Free Conditions

  1. Kun Xu,
  2. Yanbin Hu,
  3. Sheng Zhang,
  4. Zhenggen Zha,
  5. Prof. Zhiyong Wang*

Article first published online: 28 JUN 2012

DOI: 10.1002/chem.201201203

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 18, Issue 32, pages 9793–9797, August 6, 2012

Additional Information

How to Cite

Xu, K., Hu, Y., Zhang, S., Zha, Z. and Wang, Z. (2012), Direct Amidation of Alcohols with N-Substituted Formamides under Transition-Metal-Free Conditions. Chem. Eur. J., 18: 9793–9797. doi: 10.1002/chem.201201203

Author Information

  1. Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026 (P.R. China), Fax: (+86) 551-3603185

*Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, 230026 (P.R. China), Fax: (+86) 551-3603185

Publication History

  1. Issue published online: 28 JUL 2012
  2. Article first published online: 28 JUN 2012
  3. Manuscript Revised: 17 MAY 2012
  4. Manuscript Received: 9 APR 2012

Funded by

  • National Nature Science Foundation of China. Grant Numbers: 20932002, 20972144, 90813008, 21172205, 20772188, J1030412, 2010CB912103

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Keywords:

  • alcohols;
  • amides;
  • dimethylformamide;
  • radical reactions;
  • transition-metal-free reactions
Thumbnail image of graphical abstract

Go tandem! The first example of the direct amidation of alcohols with N-substituted formamides has been developed. A series of tertiary amides, including the challenging N,N-dimethyl-substituted amides, were obtained in moderate to good yields under transition-metal-free conditions (see scheme). TBHP=tert-butyl hydroperoxide.

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