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Communication
Transition Metal and Hydrogen Bond Donor Hybrids: Catalysts for the Activation of Alkylidene Malonates
Article first published online: 12 JUN 2012
DOI: 10.1002/chem.201201206
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Additional Information
How to Cite
Nickerson, D. M. and Mattson, A. E. (2012), Transition Metal and Hydrogen Bond Donor Hybrids: Catalysts for the Activation of Alkylidene Malonates. Chem. Eur. J., 18: 8310–8314. doi: 10.1002/chem.201201206
Publication History
- Issue published online: 22 JUN 2012
- Article first published online: 12 JUN 2012
- Manuscript Received: 9 APR 2012
Funded by
- OSU Department of Chemistry
Keywords:
- alkylidene malonate;
- catalysis;
- hydrogen bond donor;
- organocatalysis;
- palladacycles
Palladium ureaka! Urea palladacycles are introduced to activate alkylidene malonates for nucleophilic attack. The strategic incorporation of palladium on a urea scaffold give rise to urea catalysts with enhanced reactivity when compared to conventional urea and thiourea catalysts. A variety of alkylidene malonates are easily activated with urea palladacycle catalysts giving rise to the corresponding products in high yield (see scheme).