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Brønsted Acid Enhanced Rhodium-Catalyzed Conjugate Addition of Aryl C[BOND]H Bonds to α,β-Unsaturated Ketones under Mild Conditions

Authors

  • Dr. Lei Yang,

    1. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 (P.R. China), Fax: (+86) 931-496-8129
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  • Bo Qian,

    1. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 (P.R. China), Fax: (+86) 931-496-8129
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  • Prof. Dr. Hanmin Huang

    Corresponding author
    1. State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 (P.R. China), Fax: (+86) 931-496-8129
    2. State Key Laboratory of Applied Organic Chemistry, Lanzhou University Lanzhou, 730000 (P.R. China)
    • State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 (P.R. China), Fax: (+86) 931-496-8129
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Abstract

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Acid test: With a Brønsted acid as the solvent, the rhodium-catalyzed direct addition of aryl C[BOND]H bonds to α,β-unsaturated ketones was realized under mild reaction conditions (see scheme). The acid may assist by interceding in the conflict of the two proton-transfer events and averting the substrate inhibition involved in this type of C[BOND]H addition reaction.

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