Communication

The Remarkable Effect of a Simple Ion: Iodide-Promoted Transfer Hydrogenation of Heteroaromatics

  1. Jianjun Wu1,
  2. Dr. Chao Wang2,
  3. Dr. Weijun Tang1,
  4. Dr. Alan Pettman3,
  5. Prof. Jianliang Xiao1,*

Article first published online: 26 JUN 2012

DOI: 10.1002/chem.201201517

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 18, Issue 31, pages 9525–9529, July 27, 2012

Additional Information

How to Cite

Wu, J., Wang, C., Tang, W., Pettman, A. and Xiao, J. (2012), The Remarkable Effect of a Simple Ion: Iodide-Promoted Transfer Hydrogenation of Heteroaromatics. Chem. Eur. J., 18: 9525–9529. doi: 10.1002/chem.201201517

Author Information

  1. 1

    Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)

  2. 2

    School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710062 (P.R. China)

  3. 3

    Chemical R & D, Global Research & Development, Pfizer, Sandwich, Kent CT13 9NJ (UK)

*Department of Chemistry, University of Liverpool, Liverpool L69 7ZD (UK)

Publication History

  1. Issue published online: 20 JUL 2012
  2. Article first published online: 26 JUN 2012
  3. Manuscript Received: 1 MAY 2012

Funded by

  • Pfizer
  • AstraZeneca for support

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Keywords:

  • formic acid;
  • heterocycles;
  • hydrogenation;
  • iodine;
  • rhodium
Thumbnail image of graphical abstract

I can do it! Accelerated by simple iodide ions, rhodium-catalysed transfer hydrogenation can be readily performed on quinolines, isoquinolines and quinoxalines, affording the tetrahydro products in high yields with low catalyst loading (see scheme).

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