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Keywords:

  • asymmetric catalysis;
  • C[BOND]H activation;
  • hydrogen transfer;
  • Lewis acid;
  • phosphoric acid
Thumbnail image of graphical abstract

Selective H transfer by ABC: A new asymmetric binary acid catalyst was developed to promote 1,5-H transfer specifically and stereoselectively in tert-aminocyclization reactions with excellent activity, high enantioselectivity, and broad substrate scope. The H atom (in red) was proven to transfer through a stereospecific suprafacial pathway (see scheme).