Communication

Flash Generation of a Highly Reactive Pd Catalyst for Suzuki–Miyaura Coupling by Using a Flow Microreactor

  1. Dr. Aiichiro Nagaki,
  2. Naofumi Takabayashi,
  3. Yuya Moriwaki,
  4. Prof. Jun-ichi Yoshida*

Article first published online: 17 AUG 2012

DOI: 10.1002/chem.201201579

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 18, Issue 38, pages 11871–11875, September 17, 2012

Additional Information

How to Cite

Nagaki, A., Takabayashi, N., Moriwaki, Y. and Yoshida, J.-i. (2012), Flash Generation of a Highly Reactive Pd Catalyst for Suzuki–Miyaura Coupling by Using a Flow Microreactor. Chem. Eur. J., 18: 11871–11875. doi: 10.1002/chem.201201579

Author Information

  1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727

*Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727

Publication History

  1. Issue published online: 10 SEP 2012
  2. Article first published online: 17 AUG 2012
  3. Manuscript Received: 6 MAY 2012

Funded by

  • Grants-in-Aid for Scientific Research on Innovative Areas. Grant Number: 2105

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Keywords:

  • cross-coupling;
  • microreactors;
  • Suzuki–Miyaura coupling;
  • palladium
Thumbnail image of graphical abstract

Superflash! Flash chemistry enables the use of highly reactive unstable species as catalysts for chemical synthesis. Fast micromixing of a solution of [Pd(OAc)2] and that of tBu3P in 1:1 mole ratio gave a solution of a highly reactive unstable species, which was immediately transferred to a vessel by using a flow microreactor, in which Suzuki–Miyaura coupling was conducted (see scheme).

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