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Flash Generation of a Highly Reactive Pd Catalyst for Suzuki–Miyaura Coupling by Using a Flow Microreactor

Authors

  • Dr. Aiichiro Nagaki,

    1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
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  • Naofumi Takabayashi,

    1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
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  • Yuya Moriwaki,

    1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
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  • Prof. Jun-ichi Yoshida

    Corresponding author
    1. Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
    • Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University Nishikyo-ku, Kyoto, 615-8510 (Japan), Fax: (+81) 75-383-2727
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Abstract

original image

Superflash! Flash chemistry enables the use of highly reactive unstable species as catalysts for chemical synthesis. Fast micromixing of a solution of [Pd(OAc)2] and that of tBu3P in 1:1 mole ratio gave a solution of a highly reactive unstable species, which was immediately transferred to a vessel by using a flow microreactor, in which Suzuki–Miyaura coupling was conducted (see scheme).

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