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Nitric Oxide Donor-Based Platinum Complexes as Potential Anticancer Agents

Authors

  • Jian Zhao,

    1. Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189 (P. R. China), Fax: (+86) 83272381
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  • Prof. Dr. Shaohua Gou,

    Corresponding author
    1. Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189 (P. R. China), Fax: (+86) 83272381
    2. Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing 211189 (P. R. China)
    • Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189 (P. R. China), Fax: (+86) 83272381===

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  • Yanyan Sun,

    1. Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189 (P. R. China), Fax: (+86) 83272381
    2. Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing 211189 (P. R. China)
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  • Dr. Runting Yin,

    1. Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189 (P. R. China), Fax: (+86) 83272381
    2. Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing 211189 (P. R. China)
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  • Zhimei Wang

    1. Pharmaceutical Research Center, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189 (P. R. China), Fax: (+86) 83272381
    2. Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, Southeast University, Nanjing 211189 (P. R. China)
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Abstract

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Joining forces: Platinum complexes containing organic nitrate ligands were investigated as anticancer agents. The complexes, which were stable in aqueous solution, showed cytotoxicity that was superior to that of the corresponding parent compound (carboplatin), thus suggesting an interesting synergy between the ability of the nitrate-based ligands to release nitric oxide and the ability of the platinum moiety to inhibit DNA synthesis (see scheme).

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