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Gold Nanoparticles Grown on Ionic Liquid-Functionalized Single-Walled Carbon Nanotubes: New Materials for Photothermal Therapy

Authors

  • Dr. Lingjie Meng,

    1. School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, 200240. (P.R. China), Fax: (+86) 21-54747535
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  • Lvye Niu,

    1. School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, 200240. (P.R. China), Fax: (+86) 21-54747535
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  • Ling Li,

    1. School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, 200240. (P.R. China), Fax: (+86) 21-54747535
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  • Prof. Qinghua Lu,

    Corresponding author
    1. School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, 200240. (P.R. China), Fax: (+86) 21-54747535
    • School of Chemistry and Chemical Technology, Shanghai Jiao Tong University, Shanghai, 200240. (P.R. China), Fax: (+86) 21-54747535
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  • Dr. Zhaofu Fei,

    1. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne. (Switzerland)
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  • Prof. Paul J. Dyson

    Corresponding author
    1. Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne. (Switzerland)
    • Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne. (Switzerland)
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Abstract

Gold nanoparticles were grown on single-walled carbon nanotubes (SWNTs) coated with a thiol-functionalized ionic liquid resulting in the formation of core-shell structures referred to as SWNT-IL-Au nanohybrid materials. The nanohybrid materials were characterized by high-resolution transmission electron microscopy (HR-TEM), Raman-, and UV/Vis absorption spectroscopy. The nanohybrid materials were found to enter lysosomes in HeLa cells and show negligible cytotoxicity. Interestingly, they have an enhanced NIR absorption that is effectively transferred into heat to cause localized hyperthermia, resulting in rapid cell death; overall, the material appears to have excellent properties for photothermal therapeutic applications.

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