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Colorimetric Enantiorecognition of Oligopeptide and Logic Gate Construction Based on DNA Aptamer–Ligand–Gold Nanoparticle Interactions

Authors

  • Jiangtao Ren,

    1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 (P.R. China)
    2. University of Chinese Academy of Sciences, Beijing, 100049 (P.R. China)
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  • Prof. Jiahai Wang,

    1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 (P.R. China)
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  • Prof. Jin Wang,

    Corresponding author
    1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 (P.R. China)
    2. Department of Chemistry and Physics, State University of New York at Stony Brook, New York 11794 (USA)
    • State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 (P.R. China)
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  • Prof. Erkang Wang

    Corresponding author
    1. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 (P.R. China)
    • State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022 (P.R. China)
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Abstract

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At the gate: Colorimetric enantiorecognition of one oligopeptide was realized by virtue of a D-enantiomer specific DNA aptamer as chiral selector and unmodified gold nanoparticles as indicator. Oligopeptide enantiomers as inputs were introduced into colorimetric logic gates, which have the potential for enantiorecognition of oligopeptides (see figure). This system may lead to a better understanding of chiral recognition for information processing in natural systems.

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