Poly(acrylic acid)-Modified Fe3O4 Microspheres for Magnetic-Targeted and pH-Triggered Anticancer Drug Delivery

Authors

  • Dr. Xiao-Jiao Kang,

    1. State Key Laboratory of Rare Earth Resource, Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (P. R. China), Fax: (+86) 431-85698041
    2. University of the Chinese Academy of Sciences, Beijing 100049 (P. R. China)
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  • Dr. Yun-Lu Dai,

    1. State Key Laboratory of Rare Earth Resource, Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (P. R. China), Fax: (+86) 431-85698041
    2. University of the Chinese Academy of Sciences, Beijing 100049 (P. R. China)
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  • Dr. Ping-An Ma,

    1. State Key Laboratory of Rare Earth Resource, Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (P. R. China), Fax: (+86) 431-85698041
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  • Dr. Dong-Mei Yang,

    1. State Key Laboratory of Rare Earth Resource, Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (P. R. China), Fax: (+86) 431-85698041
    2. University of the Chinese Academy of Sciences, Beijing 100049 (P. R. China)
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  • Dr. Chun-Xia Li,

    1. State Key Laboratory of Rare Earth Resource, Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (P. R. China), Fax: (+86) 431-85698041
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  • Dr. Zhi-Yao Hou,

    1. State Key Laboratory of Rare Earth Resource, Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (P. R. China), Fax: (+86) 431-85698041
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  • Dr. Zi-Yong Cheng,

    Corresponding author
    1. State Key Laboratory of Rare Earth Resource, Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (P. R. China), Fax: (+86) 431-85698041
    • State Key Laboratory of Rare Earth Resource, Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (P. R. China), Fax: (+86) 431-85698041
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  • Prof. Jun Lin

    Corresponding author
    1. State Key Laboratory of Rare Earth Resource, Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (P. R. China), Fax: (+86) 431-85698041
    • State Key Laboratory of Rare Earth Resource, Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022 (P. R. China), Fax: (+86) 431-85698041
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Abstract

Monodisperse poly(acrylic acid)-modified Fe3O4 (PAA@Fe3O4) hybrid microspheres with dual responses (magnetic field and pH) were successfully fabricated. The PAA polymer was encapsulated into the inner cavity of Fe3O4 hollow spheres by a vacuum-casting route and photo-initiated polymerization. TEM images show that the samples consist of monodisperse porous spheres with a diameter around 200 nm. The Fe3O4 spheres, after modification with the PAA polymer, still possess enough space to hold guest molecules. We selected doxorubicin (DOX) as a model drug to investigate the drug loading and release behavior of as-prepared composites. The release of DOX molecules was strongly dependent on the pH value due to the unique property of PAA. The HeLa cell-uptake process of DOX-loaded PAA@Fe3O4 was observed by confocal laser scanning microscopy (CLSM). After being incubated with HeLa cells under magnet magnetically guided conditions, the cytotoxtic effects of DOX-loaded PAA@Fe3O4 increased. These results indicate that pH-responsive magnetic PAA@Fe3O4 spheres have the potential to be used as anticancer drug carriers.

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