Cobalt(II)-Catalyzed 1,4-Addition of Organoboronic Acids to Activated Alkenes: An Application to Highly cis-Stereoselective Synthesis of Aminoindane Carboxylic Acid Derivatives



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It all adds up: The 1,4-addition of organoboronic acids to activated alkenes catalyzed by [Co(dppe)Cl2] is described. A [3+2]-annulation reaction of ortho-iminoarylboronic acids with acrylates to give various aminoindane carboxylic acid derivatives with cis-stereoselectivity is also demonstrated (see scheme; dppe=1,2-bis(diphenylphosphino)ethane).