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A Base-Promoted Tandem Cycloaddition/Air Oxidation Reaction of Electron-Deficient Conjugated Enynes and Hydrazines: Synthesis of Highly Substituted Pyrazoles

  1. Dr. Xiuzhao Yu1,
  2. Prof. Dr. Junliang Zhang1,2,*

Article first published online: 5 SEP 2012

DOI: 10.1002/chem.201202583

Issue

Chemistry - A European Journal

Chemistry - A European Journal

Volume 18, Issue 41, pages 12945–12949, October 8, 2012

Additional Information

How to Cite

Yu, X. and Zhang, J. (2012), A Base-Promoted Tandem Cycloaddition/Air Oxidation Reaction of Electron-Deficient Conjugated Enynes and Hydrazines: Synthesis of Highly Substituted Pyrazoles. Chem. Eur. J., 18: 12945–12949. doi: 10.1002/chem.201202583

Author Information

  1. 1

    Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062 (P.R. China), Fax: (+86) 21-6223-5039

  2. 2

    State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, (P.R. China)

*Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062 (P.R. China), Fax: (+86) 21-6223-5039

Publication History

  1. Issue published online: 27 SEP 2012
  2. Article first published online: 5 SEP 2012
  3. Manuscript Received: 23 JUL 2012

Funded by

  • National Natural Science Foundation. Grant Number: 20972054
  • Ministry of Education. Grant Number: 2011CB808600

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Keywords:

  • cycloaddition;
  • enynes;
  • hydrazines;
  • oxidation;
  • pyrazoles
Thumbnail image of graphical abstract

Rapid access: A base-mediated cycloaddition/oxidation reaction of hydrazines and electron-deficient 1,3-conjugated enynes gives pyrazole derivatives, some of which are not easily accessible by other methods (see scheme). The reaction conditions are mild, thus enabling a variety of functional groups to be tolerated.

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