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NIS-Catalyzed Reactions: Amidation of Acetophenones and Oxidative Amination of Propiophenones

Authors

  • Manjunath Lamani,

    1. Department of Organic chemistry Indian Institute of Science, Bangalore 560 012, Karnataka (India), Fax: (+91) 80-23600529
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  • Dr. Kandikere Ramaiah Prabhu

    Corresponding author
    1. Department of Organic chemistry Indian Institute of Science, Bangalore 560 012, Karnataka (India), Fax: (+91) 80-23600529
    • Department of Organic chemistry Indian Institute of Science, Bangalore 560 012, Karnataka (India), Fax: (+91) 80-23600529
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Abstract

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Single-step amination: The N-iodosuccinimide (NIS)-catalyzed amidation of acetophenone derivatives by using tert-butylhydroperoxide (TBHP) as an oxidant is presented. A variety of acetyl derivatives of heterocyclic compounds were easily converted to their corresponding ketoamides under these conditions. A new, NIS-catalyzed amination of propiophenone and its derivatives in the presence of TBHP to furnish the corresponding 2-aminoketone derivatives is the first reported single-step amination of propiophenone derivatives.

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