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Transition-Metal-Free Atropo-Selective Synthesis of Biaryl Compounds Based on Arynes

Authors

  • Dr. Frédéric R. Leroux,

    Corresponding author
    1. Laboratoire de Chimie Moléculaire (UMR7509/CNRS/ECPM), Université de Strasbourg, 25 Rue Becquerel, 67087 Strasbourg (France), Fax: (+33) 3-68-85-27-42
    • Laboratoire de Chimie Moléculaire (UMR7509/CNRS/ECPM), Université de Strasbourg, 25 Rue Becquerel, 67087 Strasbourg (France), Fax: (+33) 3-68-85-27-42===

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  • Anaïs Berthelot,

    1. Laboratoire de Chimie Moléculaire (UMR7509/CNRS/ECPM), Université de Strasbourg, 25 Rue Becquerel, 67087 Strasbourg (France), Fax: (+33) 3-68-85-27-42
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  • Dr. Laurence Bonnafoux,

    1. Laboratoire de Chimie Moléculaire (UMR7509/CNRS/ECPM), Université de Strasbourg, 25 Rue Becquerel, 67087 Strasbourg (France), Fax: (+33) 3-68-85-27-42
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  • Dr. Armen Panossian,

    1. Laboratoire de Chimie Moléculaire (UMR7509/CNRS/ECPM), Université de Strasbourg, 25 Rue Becquerel, 67087 Strasbourg (France), Fax: (+33) 3-68-85-27-42
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  • Prof. Françoise Colobert

    Corresponding author
    1. Laboratoire de Chimie Moléculaire (UMR7509/CNRS/ECPM), Université de Strasbourg, 25 Rue Becquerel, 67087 Strasbourg (France), Fax: (+33) 3-68-85-27-42
    • Laboratoire de Chimie Moléculaire (UMR7509/CNRS/ECPM), Université de Strasbourg, 25 Rue Becquerel, 67087 Strasbourg (France), Fax: (+33) 3-68-85-27-42===

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Abstract

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A modular way towards biaryls: Highly enantioenriched biphenyls can be prepared based on a transition-metal-free aryl–aryl coupling followed by efficient desymmetrization or deracemization and chemoselective functionalization (see scheme).

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