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Syntheses and Applications of Monofluorinated Cyclopropanes

Authors

  • Dr. Emilie David,

    1. INSA de Rouen and Université de Rouen, CNRS, UMR 6014 & FR 3038, COBRA, IRCOF, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex (France), Fax: (+33) 2 35 52 29 59
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  • Gaëlle Milanole,

    1. INSA de Rouen and Université de Rouen, CNRS, UMR 6014 & FR 3038, COBRA, IRCOF, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex (France), Fax: (+33) 2 35 52 29 59
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  • Pavel Ivashkin,

    1. INSA de Rouen and Université de Rouen, CNRS, UMR 6014 & FR 3038, COBRA, IRCOF, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex (France), Fax: (+33) 2 35 52 29 59
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  • Dr. Samuel Couve-Bonnaire,

    1. INSA de Rouen and Université de Rouen, CNRS, UMR 6014 & FR 3038, COBRA, IRCOF, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex (France), Fax: (+33) 2 35 52 29 59
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  • Prof. Dr. Philippe Jubault,

    Corresponding author
    1. INSA de Rouen and Université de Rouen, CNRS, UMR 6014 & FR 3038, COBRA, IRCOF, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex (France), Fax: (+33) 2 35 52 29 59
    • INSA de Rouen and Université de Rouen, CNRS, UMR 6014 & FR 3038, COBRA, IRCOF, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex (France), Fax: (+33) 2 35 52 29 59
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  • Prof. Dr. Xavier Pannecoucke

    1. INSA de Rouen and Université de Rouen, CNRS, UMR 6014 & FR 3038, COBRA, IRCOF, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex (France), Fax: (+33) 2 35 52 29 59
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Abstract

The combination of a fluorine atom and a cyclopropane ring, which both possess unique structural and chemical features, can generate new relevant building blocks for the discovery of efficient fluorinated biologically active agents. In this review, we report the different strategies to access monofluorocyclopropanes and highlight some of their attractive biological applications.

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