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Direct sp3 C[BOND]H Amination of Nitrogen-Containing Benzoheterocycles Mediated by Visible-Light-Photoredox Catalysts

Authors

  • Dr. Yoshihiro Miyake,

    1. Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113-8656 (Japan)
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  • Kazunari Nakajima,

    1. Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113-8656 (Japan)
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  • Assoc. Prof. Dr. Yoshiaki Nishibayashi

    Corresponding author
    1. Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113-8656 (Japan)
    • Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, 113-8656 (Japan)===

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Abstract

Visible-light-mediated direct sp3 C[BOND]H amination of benzocyclic amines via α-aminoalkyl radicals by using photoredox catalysts is described here. The obtained N,N-acetals were also successfully applied for carbon–carbon bond forming reactions with carbon nucleophiles. The procedure is suitable for a late-stage modification of C[BOND]H bonds to C[BOND]C bonds.

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