Synchronizing Steric and Electronic Effects in {RuII(NNNN,P)} Complexes: The Catalytic Dehydrative Alkylation of Anilines by Using Alcohols as a Case Study

Authors

  • Dipl.-Chem. Daniel Weickmann,

    1. Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart (Germany), Fax: (+49) 711-685-64285
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  • Dr. Wolfgang Frey,

    1. Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart (Germany), Fax: (+49) 711-685-64285
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  • Prof. Dr. Bernd Plietker

    Corresponding author
    1. Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart (Germany), Fax: (+49) 711-685-64285
    • Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart (Germany), Fax: (+49) 711-685-64285
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Abstract

A series of new hexacoordinated {RuII(NNNN,P)} complexes was prepared from [RuCl2(R3P)3]. Their structure was determined by X-ray crystallography. The catalytic potential of this new class of complexes was tested in the alkylation of aniline with benzyl alcohol. In this test reaction, the influence of the counteranion plus electronic influences at the tetradentate ligand and the phosphine ligand were examined. The electrochemistry of all complexes was studied by cyclic voltammetry. Depending on the substituent at the ligand backbone, the complexes showed a different behavior. For all N-benzyl substituted complexes, reversible RuII/III redox potentials were observed, whereas the N-methyl substituted complex possessed an irreversible oxidation event at small scan rates. Furthermore, the electronic influence of different substituents at the ligand scaffold and at the phosphine on the RuII/III redox potential was investigated. The measured E0 values were correlated to the theoretically determined HOMO energies of the complexes. In addition, these HOMO energies correlated well with the reactivity of the single complexes in the alkylation of aniline with benzyl alcohol. The exact balance of redox potential and reactivity appears to be crucial for synchronizing the multiple hydrogen-transfer events. The optimized catalyst structure was applied in a screening on scope and limitation in the catalytic dehydrative alkylation of anilines by using alcohols.

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