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Self-Organization of Honeycomb-like Porous TiO2 Films by means of the Breath-Figure Method for Surface Modification of Titanium Implants

Authors

  • Hong Li,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China), Fax: (+86) 10-82612629
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  • Dr. Yi Jia,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China), Fax: (+86) 10-82612629
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  • Dr. Mingchun Du,

    1. Division of Nanobiomedicine Research, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123 (P.R. China)
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  • Dr. Jinbo Fei,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China), Fax: (+86) 10-82612629
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  • Dr. Jie Zhao,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China), Fax: (+86) 10-82612629
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  • Dr. Yue Cui,

    1. Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China), Fax: (+86) 10-82612629
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  • Prof. Dr. Junbai Li

    Corresponding author
    1. Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China), Fax: (+86) 10-82612629
    • Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Lab of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190 (P.R. China), Fax: (+86) 10-82612629
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Abstract

This study describes a facile breath-figure method for the preparation of honeycomb-like porous TiO2 films with an organometallic small-molecule precursor. Multiple characterization techniques have been used to investigate the porous films and a mechanism for the formation process of porous TiO2 films through the breath-figure method is proposed. The pore size of the TiO2 films could be modulated by varying the experimental parameters, such as the concentration of titanium n-butoxide (TBT) solution, the content of cosolvent, and the air flow rate. In vitro cell-culture experiments indicate that NIH 3T3 fibroblast cells seeded on the honeycomb-like porous TiO2 films show good adhesion, spreading, and proliferation behaviors, which suggests that honeycomb-like porous TiO2 films are an attractive biomaterial for surface modification of titanium and its alloys implants in tissue engineering to enhance their biocompatibility and bioactivity.

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