Well-connected: The palladium-catalyzed addition of indoles to nitriles affords 3-acylindoles. The reaction proceeds with high selectivity, wide substrate scope, broadly available starting materials, and an operationally simple procedure. Combination with the palladium-catalyzed intramolecular oxidative coupling of 3-indolylarylketone gives access to indenoindolones in a one-pot synthesis.
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