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Facile Access to 3-Acylindoles through Palladium-Catalyzed Addition of Indoles to Nitriles: The One-Pot Synthesis of Indenoindolones

Authors

  • Yuanhong Ma,

    1. Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P. R. China), Fax: (+86) 28-85412203
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  • Prof. Dr. Jingsong You,

    Corresponding author
    1. Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P. R. China), Fax: (+86) 28-85412203
    • Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P. R. China), Fax: (+86) 28-85412203
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  • Dr. Feijie Song

    Corresponding author
    1. Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P. R. China), Fax: (+86) 28-85412203
    • Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064 (P. R. China), Fax: (+86) 28-85412203
    Search for more papers by this author

Abstract

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Well-connected: The palladium-catalyzed addition of indoles to nitriles affords 3-acylindoles. The reaction proceeds with high selectivity, wide substrate scope, broadly available starting materials, and an operationally simple procedure. Combination with the palladium-catalyzed intramolecular oxidative coupling of 3-indolylarylketone gives access to indenoindolones in a one-pot synthesis.

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