E/Z Oxime Isomerism in PhC(NOH)CN

Authors

  • Prof. D. Scott Bohle,

    Corresponding author
    1. Department of Chemistry, McGill University, 801 Sherbrooke St. W. Montreal, H3A 2K6, Quebec (Canada), Fax: (+1) 514-398-3797
    • Department of Chemistry, McGill University, 801 Sherbrooke St. W. Montreal, H3A 2K6, Quebec (Canada), Fax: (+1) 514-398-3797

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  • Zhijie Chua,

    1. Department of Chemistry, McGill University, 801 Sherbrooke St. W. Montreal, H3A 2K6, Quebec (Canada), Fax: (+1) 514-398-3797
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  • Dr. Inna Perepichka,

    1. Department of Chemistry, McGill University, 801 Sherbrooke St. W. Montreal, H3A 2K6, Quebec (Canada), Fax: (+1) 514-398-3797
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  • Kristopher Rosadiuk

    1. Department of Chemistry, McGill University, 801 Sherbrooke St. W. Montreal, H3A 2K6, Quebec (Canada), Fax: (+1) 514-398-3797
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Abstract

The reaction of nitric oxide with benzyl cyanide in the presence of potassium methoxide at low temperature gave the dipotassium salt of a bis-diazeniumdiolate 2 in excellent yield. Two new stereospecific syntheses of E or Z 2-(hydroxyimino)-2-phenylacetonitrile from 2 have been found. The thermodynamics of the E/Z isomerization has been investigated spectroscopically in solution, in the solid state by differential scanning calorimetry (DSC), and theoretically in the gas phase. Evidence of catalysis by NO of E/Z oxime isomerization has been observed.

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