Direct Conjugate Addition of Alkynes with α,β-Unsaturated Carbonyl Compounds Catalyzed by NCN-Pincer Ru Complexes

Authors

  • Dr. Jun-ichi Ito,

    Corresponding author
    1. Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603 (Japan), Fax: (+81) 52-789-3209
    • Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603 (Japan), Fax: (+81) 52-789-3209
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  • Kohei Fujii,

    1. Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603 (Japan), Fax: (+81) 52-789-3209
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  • Prof. Dr. Hisao Nishiyama

    Corresponding author
    1. Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603 (Japan), Fax: (+81) 52-789-3209
    • Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603 (Japan), Fax: (+81) 52-789-3209
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Abstract

NCN-pincer Ru-complexes containing bis(oxazolinyl)phenyl ligands serve as suitable catalysts in the direct conjugate additions of α,β-unsaturated carbonyl compounds, including ketones, esters, and amides, as well as vinylphosphonates, giving various β-alkynyl carbonyl and phosphonate compounds. A bis(oxazolinyl)phenyl (phebox)–Ru complex also catalyzes the asymmetric conjugate addition of an alkyne with a β-substituted, α,β-unsaturated ketone to produce a chiral β-alkynyl ketone.

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