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Assembly of Spirooxindole Derivatives Containing Four Consecutive Stereocenters by Using Cascade Reactions Catalyzed by an N-Heterocyclic Carbene

Authors

  • Dr. Bing Zhou,

    Corresponding author
    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (P.R. China), Fax: (+86) 21-50807288
    • Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (P.R. China), Fax: (+86) 21-50807288
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  • Dr. Zhi Luo,

    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (P.R. China), Fax: (+86) 21-50807288
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  • Prof. Dr. Yuanchao Li

    Corresponding author
    1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (P.R. China), Fax: (+86) 21-50807288
    • Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203 (P.R. China), Fax: (+86) 21-50807288
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Abstract

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In-spiro-ational: Biologically important and synthetically challenging spirocyclopentaneoxindoles with four consecutive stereocenters, including one spiroquaternary stereocenter, have been constructed in good yields and diastereoselectivity by a cascade reaction catalyzed by an N-heterocyclic carbene (see scheme). This reaction also provides a new strategy to access highly unusual tricyclic oxindoles.

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