Water-Soluble and pH-Responsive Polymeric Nanotubes from Cyclic Peptide Templates



Water-soluble organic nanotubes were prepared by convergently conjugating polymers of hydroxyethyl acrylate (HEA) and acrylic acid (AA) to self-assembling cyclic octapeptides of alternating D and L chirality. The structure of the self-assembled tubes was characterised in a number of polar solvents, and notably water, by using light scattering, TEM and small angle neutron scattering (SANS) techniques. In addition, the self-assembly into tubes could be controlled by exploiting the pH responsiveness of acrylic acid polymers.