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Bis(phosphite) Ligands with Distal Regulation: Application in Rhodium-mediated Asymmetric Hydroformylations

Authors

  • Ignasi Mon,

    1. Institute of Chemical Research of Catalonia (ICIQ), Avgda. Països Catalans 16, 43007 Tarragona (Spain), Fax: (+34) 977920228
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  • Dr. D. Amilan Jose,

    1. Institute of Chemical Research of Catalonia (ICIQ), Avgda. Països Catalans 16, 43007 Tarragona (Spain), Fax: (+34) 977920228
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  • Prof. Anton Vidal-Ferran

    Corresponding author
    1. Institute of Chemical Research of Catalonia (ICIQ), Avgda. Països Catalans 16, 43007 Tarragona (Spain), Fax: (+34) 977920228
    2. Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluís Companys 23, 08010 Barcelona (Spain)
    • Institute of Chemical Research of Catalonia (ICIQ), Avgda. Països Catalans 16, 43007 Tarragona (Spain), Fax: (+34) 977920228
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Abstract

Small amounts of achiral polyether binders are employed to enhance the enantioselectivity of the hydroformylation of an array of diversely substituted substrates (increase of up to 62 % ee for vinyl acetate) mediated by chiral rhodium complexes derived from the α,ω-bis(phosphite)–polyether ligands 1. To the best of our knowledge, this study represents an unprecedented successful example of the positive regulation of enantioselectivity in hydroformylations.

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