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Synthesis, Characterisation and In Vitro Anticancer Activity of Hexanuclear Thiolato-Bridged Arene Ruthenium Metalla-Prisms

Authors

  • Dr. Mona A. Furrer,

    1. Institute of Chemistry, University of Neuchatel, Ave de Bellevaux 51, 2000 Neuchatel (Switzerland), Fax: (+41) 32 718 2511
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  • Amine Garci,

    1. Institute of Chemistry, University of Neuchatel, Ave de Bellevaux 51, 2000 Neuchatel (Switzerland), Fax: (+41) 32 718 2511
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  • Emmanuel Denoyelle-Di-Muro,

    1. Institute of Chemistry, University of Neuchatel, Ave de Bellevaux 51, 2000 Neuchatel (Switzerland), Fax: (+41) 32 718 2511
    2. Faculté de Pharmacie, Université de Limoges, 2 Rue du Dr. Marcland, 87025 Limoges (France)
    3. Laboratoire de Chimie des Matériaux Nouveaux, Université de Mons, Place du Parc 20, 7000 Mons (Belgium)
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  • Dr. Patrick Trouillas,

    1. Faculté de Pharmacie, Université de Limoges, 2 Rue du Dr. Marcland, 87025 Limoges (France)
    2. Laboratoire de Chimie des Matériaux Nouveaux, Université de Mons, Place du Parc 20, 7000 Mons (Belgium)
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  • Federico Giannini,

    1. Departement für Chemie und Biochemie, Universität Bern, Freiestrasse 3, 3012 Bern (Switzerland)
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  • Dr. Julien Furrer,

    1. Departement für Chemie und Biochemie, Universität Bern, Freiestrasse 3, 3012 Bern (Switzerland)
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  • Catherine M. Clavel,

    1. Institut des Sciences et Ingénierie Chimique, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
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  • Prof. Dr. Paul J. Dyson,

    1. Institut des Sciences et Ingénierie Chimique, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne (Switzerland)
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  • Prof. Dr. Georg Süss-Fink,

    1. Institute of Chemistry, University of Neuchatel, Ave de Bellevaux 51, 2000 Neuchatel (Switzerland), Fax: (+41) 32 718 2511
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  • Prof. Dr. Bruno Therrien

    Corresponding author
    1. Institute of Chemistry, University of Neuchatel, Ave de Bellevaux 51, 2000 Neuchatel (Switzerland), Fax: (+41) 32 718 2511
    • Institute of Chemistry, University of Neuchatel, Ave de Bellevaux 51, 2000 Neuchatel (Switzerland), Fax: (+41) 32 718 2511
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Abstract

Hexanuclear thiolato-bridged arene ruthenium metalla-prisms of the general formula [(p-cymene)6Ru6(SR)6(tpt)2]6+ (R=CH2Ph, CH2C6H4-p-tBu, CH2CH2Ph; tpt=2,4,6-tris(4-pyridyl)-1,3,5-triazine), obtained from the dinuclear precursors [(p-cymene)2Ru2(SR)2Cl2], AgCF3SO3 and tpt, have been isolated and fully characterised as triflate salts. The metalla-prisms are highly cytotoxic against human ovarian cancer cells, especially towards the cisplatin-resistant cell line A2780cisR (IC50 <0.25 μM).

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