Size-Selective Encapsulation of Hydrophobic Guests by Self-Assembled M4L6 Cobalt and Nickel Cages

Authors

  • Dr. Tanya K. Ronson,

    1. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)
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  • Chandan Giri,

    1. Department of Chemistry, Nanoscience Center, University of Jyväskylä, P. O. Box 35, 40014 Jyväskylä (Finland)
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  • Dr. N. Kodiah Beyeh,

    1. Department of Chemistry, Nanoscience Center, University of Jyväskylä, P. O. Box 35, 40014 Jyväskylä (Finland)
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  • Antti Minkkinen,

    1. Department of Chemistry, Nanoscience Center, University of Jyväskylä, P. O. Box 35, 40014 Jyväskylä (Finland)
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  • Filip Topić,

    1. Department of Chemistry, Nanoscience Center, University of Jyväskylä, P. O. Box 35, 40014 Jyväskylä (Finland)
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  • Dr. Julian J. Holstein,

    1. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)
    2. Global Phasing Ltd., Sheraton House, Castle Park, Cambridge, CB3 0AX (UK)
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  • Prof. Kari Rissanen,

    Corresponding author
    1. Department of Chemistry, Nanoscience Center, University of Jyväskylä, P. O. Box 35, 40014 Jyväskylä (Finland)
    • Kari Rissanen, Department of Chemistry, Nanoscience Center, University of Jyväskylä, P. O. Box 35, 40014 Jyväskylä (Finland)

      Jonathan R. Nitschke, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)

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  • Dr. Jonathan R. Nitschke

    Corresponding author
    1. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)
    • Kari Rissanen, Department of Chemistry, Nanoscience Center, University of Jyväskylä, P. O. Box 35, 40014 Jyväskylä (Finland)

      Jonathan R. Nitschke, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK)

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Abstract

Subtle differences in metal–ligand bond lengths between a series of [M4L6]4− tetrahedral cages, where M=FeII, CoII, or NiII, were observed to result in substantial differences in affinity for hydrophobic guests in water. Changing the metal ion from iron(II) to cobalt(II) or nickel(II) increases the size of the interior cavity of the cage and allows encapsulation of larger guest molecules. NMR spectroscopy was used to study the recognition properties of the iron(II) and cobalt(II) cages towards small hydrophobic guests in water, and single-crystal X-ray diffraction was used to study the solid-state complexes of the iron(II) and nickel(II) cages.

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