These authors contributed equally to this work.
Preparation of Functionalized Organoindium Reagents by Means of Magnesium Insertion into Organic Halides in the Presence of InCl3 at Room Temperature
Article first published online: 19 DEC 2012
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Chemistry - A European Journal
Volume 19, Issue 3, pages 828–833, January 14, 2013
How to Cite
Bernhardt, S., Shen, Z.-L. and Knochel, P. (2013), Preparation of Functionalized Organoindium Reagents by Means of Magnesium Insertion into Organic Halides in the Presence of InCl3 at Room Temperature. Chem. Eur. J., 19: 828–833. doi: 10.1002/chem.201203795
- Issue published online: 7 JAN 2013
- Article first published online: 19 DEC 2012
- Manuscript Received: 24 OCT 2012
- European Research Council. Grant Number: 227763
Magnesium, indium, palladium: An efficient one-pot procedure for the direct preparation of triorganoindium reagents from organic halides by means of magnesium insertion in the presence of InCl3 and LiCl is reported (see scheme). The organoindium reagents are obtained in good yields from functionalized aryl, heteroaryl, and alkyl bromides and benzyl chlorides at 25 °C in THF within 4 h. Moreover, the resulting organoindium reagents could be efficiently used as reagents in Pd-catalyzed cross-coupling reactions with a wide functional group tolerance.