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Iron-Catalyzed Oxidative Amidation of Tertiary Amines with Aldehydes

Authors

  • Yuanming Li,

    1. Department of Chemistry, Renmin University of China, Beijing 100872 (P.R. China), Fax: (+86) 10-6251-6444
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  • Fan Jia,

    1. Department of Chemistry, Renmin University of China, Beijing 100872 (P.R. China), Fax: (+86) 10-6251-6444
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  • Prof. Dr. Zhiping Li

    Corresponding author
    1. Department of Chemistry, Renmin University of China, Beijing 100872 (P.R. China), Fax: (+86) 10-6251-6444
    2. State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Beijing 102249 (P.R. China)
    • Department of Chemistry, Renmin University of China, Beijing 100872 (P.R. China), Fax: (+86) 10-6251-6444
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Abstract

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Unconventional couple: A new oxidative coupling protocol for amide bond formation has been developed (see scheme). The method provides an efficient and practical route for the synthesis of tertiary amides from readily available tertiary amines and aldehydes in the presence of a simple FeCl2 catalyst. Mechanistic studies indicated that a peroxide and an iminium ion act as the reactive intermediates in this oxidative amidation.

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