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Keywords:

  • aldol reaction;
  • asymmetric catalysis;
  • Brønsted acid;
  • cooperative effects;
  • indoles
Thumbnail image of graphical abstract

Cooperation is key! Chiral Brønsted acid/rhodium(II) cooperative catalysis enabled an enantioselective three-component aldol-type reaction of 3-diazo oxindoles and anilines with glyoxylates to give highly functionalized and structurally diverse 3-amino oxindoles in high stereoselectivity (>20:1 d.r., 99 % ee; see scheme).