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Brønsted Acid/Rhodium(II) Cooperative Catalytic Asymmetric Three-Component Aldol-Type Reaction for the Synthesis of 3-Amino Oxindoles

Authors

  • Lei Ren,

    1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (P.R. China), Fax: (+86) 551-360-6266
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  • Xiao-Lei Lian,

    1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (P.R. China), Fax: (+86) 551-360-6266
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  • Prof. Liu-Zhu Gong

    Corresponding author
    1. Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (P.R. China), Fax: (+86) 551-360-6266
    • Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (P.R. China), Fax: (+86) 551-360-6266

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Abstract

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Cooperation is key! Chiral Brønsted acid/rhodium(II) cooperative catalysis enabled an enantioselective three-component aldol-type reaction of 3-diazo oxindoles and anilines with glyoxylates to give highly functionalized and structurally diverse 3-amino oxindoles in high stereoselectivity (>20:1 d.r., 99 % ee; see scheme).

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