We announce the establishment of a new family of macrocycles—the asararenes, which are based on para-methylene linked “asarol methyl ether” (1,2,4,5-tetramethoxybenzene) units. Macrocycles with 6–12 aromatic units have been synthesized and isolated in a single step from asarol methyl ether and paraformaldehyde. Even larger rings, with up to 15 asarol methyl ether units, have been observed by high-resolution mass spectrometry. Single-crystal X-ray structures of asar-, asar-, asar-, asar-, asar- and asararene highlight the diverse structural features of this family of macrocycles. While the cavities of the asar[6–8]arene macrocycles are mostly filled with methoxyl groups, the asar- and asararene rings contain accessible cavities and self-assemble into infinite channels filled with solvent molecules in the solid state. These solid-state structures highlight the potential of this family of macrocycles for a wide range of potential applications.
If you can't find a tool you're looking for, please click the link at the top of the page to "Go to old article view". Alternatively, view our Knowledge Base articles for additional help. Your feedback is important to us, so please let us know if you have comments or ideas for improvement.