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[(η6-Praziquantel)Cr(CO)3] Derivatives with Remarkable In Vitro Anti-schistosomal Activity

Authors

  • Dr. Malay Patra,

    1. Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03
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  • Katrin Ingram,

    1. Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, P.O Box, 4002 Basel (Switzerland), Fax: (+41) 61-284-81-01
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  • Vanessa Pierroz,

    1. Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03
    2. Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland)
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  • Priv.-Doz. Dr. Stefano Ferrari,

    1. Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland)
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  • Priv.-Doz. Dr. Bernhard Spingler,

    1. Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03
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  • Prof. Dr. Robin B. Gasser,

    1. Faculty of Veterinary Science, The University of Melbourne, Parkville, Victoria 3010 (Australia)
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  • Prof. Dr. Jennifer Keiser,

    Corresponding author
    1. Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, P.O Box, 4002 Basel (Switzerland), Fax: (+41) 61-284-81-01
    • Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, University of Basel, P.O Box, 4002 Basel (Switzerland), Fax: (+41) 61-284-81-01
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  • Prof. Dr. Gilles Gasser

    Corresponding author
    1. Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03
    • Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich (Switzerland), Fax: (+41) 44-635-68-03
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Abstract

original image

The antischistosomal effect of two [(η6-praziquantel)Cr(CO)3] derivatives was investigated. The compounds (see figure: Cr purple, N blue, O red) were prepared in a one-step procedure from commercially available praziquantel. Both derivatives show a high in vitro activity against Schistosoma mansoni, a parasitic trematode, and only a minor cytotoxic effect on selected mammalian cell lines.

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