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Development of Metal/Organo Catalytic Systems for Direct Vinylogous Michael Reactions to Build Chiral γ,γ-Disubstituted Butenolides

Authors

  • Dongxu Yang,

    1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Life Sciences and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000 (P.R. China)
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  • Linqing Wang,

    1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Life Sciences and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000 (P.R. China)
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  • Dr. Depeng Zhao,

    1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Life Sciences and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000 (P.R. China)
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  • Fengxia Han,

    1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Life Sciences and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000 (P.R. China)
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  • Dr. Bangzhi Zhang,

    1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Life Sciences and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000 (P.R. China)
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  • Prof. Dr. Rui Wang

    Corresponding author
    1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Life Sciences and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000 (P.R. China)
    2. State Key Laboratory of Chiroscience, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon (Hong Kong)
    • Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Life Sciences and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000 (P.R. China)
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Errata

This article is corrected by:

  1. Errata: Corrigendum: Development of Metal/Organo Catalytic Systems for Direct Vinylogous Michael Reactions to Build Chiral γ,γ-Disubstituted Butenolides Volume 19, Issue 52, 17632, Article first published online: 18 December 2013

Abstract

original image

Vinylogous reactions: The direct asymmetric vinylogous conjugate additions of γ-aryl- and alkyl-substituted butenolides to enones was realized for the first time by a designed and tested metal/organo dual-activation strategy, in which two effective metal/organo cooperative catalytic systems have been built (see scheme).

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