Mild Copper-Mediated Direct Oxidative Cross-Coupling of 1,3,4-Oxadiazoles with Polyfluoroarenes by Using Dioxygen as Oxidant



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CH3CN and O2 do the trick! A copper-mediated direct oxidative cross-coupling of 2-(het)aryl-1,3,4-oxadiazoles with polyhaloarenes under mild reaction conditions has been developed (see scheme). The process provides a concise access to biaryl structures containing polyhaloarenes, which are of interest in the fields of pharmaceuticals and functional materials. Acetonitrile and oxygen play crucial roles.