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Selective Ruthenium-Catalyzed Transfer Hydrogenations of Nitriles to Amines with 2-Butanol

Authors

  • Svenja Werkmeister,

    1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
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  • Christoph Bornschein,

    1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
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  • Dr. Kathrin Junge,

    1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
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  • Prof. Dr. Matthias Beller

    Corresponding author
    1. Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
    • Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Straße 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-5000
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Abstract

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Transfer your hydrogen: Fast and general transfer hydrogenation of nitriles to form primary amines is possible with a homogeneous Ru/1,4-bis(diphenylphosphino)butane (DPPB) catalyst (see scheme). The use of 2-butanol as the hydrogen-transfer reagent is essential for the selective reduction of aromatic, heteroaromatic, and aliphatic nitriles with this system.

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