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Optical/Magnetic Multimodal Bioprobes Based on Lanthanide-Doped Inorganic Nanocrystals

Authors

  • Dr. Datao Tu,

    1. Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (P. R. China), Fax: (+86) 591-8764-2575
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  • Dr. Yongsheng Liu,

    1. Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (P. R. China), Fax: (+86) 591-8764-2575
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  • Dr. Haomiao Zhu,

    1. Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (P. R. China), Fax: (+86) 591-8764-2575
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  • Prof. Dr. Xueyuan Chen

    Corresponding author
    1. Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (P. R. China), Fax: (+86) 591-8764-2575
    • Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002 (P. R. China), Fax: (+86) 591-8764-2575
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Abstract

Multimodal bioprobes, which integrate the advantages of different diagnostic modes into one single particle, can overcome the current limitations of sensitivity and resolution in medical assays and significantly improve the outcome of existing therapeutics. Lanthanide-doped inorganic multimodal bioprobes, which are emerging as a promising new class of optical/magnetic multimodal bioprobes, have been long sought-after and have recently attracted revived interest owing to their distinct optical and magnetic properties. In this concept article, we introduce the controlled synthesis of lanthanide-doped inorganic multimodal bioprobes, including core–shell structured and single-phase nanoparticles, and demonstrate different design strategies for achieving dual-modal functionalization of nanoprobes. In particular, we highlight the most recent advances in biodetection, bioimaging, targeted drug delivery, and therapy based on these nanoparticles.

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