The techniques of rapid modulation and relaxation in living cells are opening up an exciting new avenue of research. Systems that are too complex to fully replicate in vitro at the present time can be studied and compared with in vivo results to see which ingredients are the most critical. Targeted in vitro studies thus become a testing ground for hypotheses based on fast dynamics imaged in vivo. For more details see the Concept article by M. Gruebele et al. on page 6420 ff.
In their Communication on page 6437 ff., L. Jiao, E. Hao et al. describe a facile one-pot synthesis of isoindoleBODIPY dyes based on nucleophilic substitution (SNAr) reactions of in situ formed chlorinated dipyrromethene by pyrrole. These novel isoindoleBODIPY dyes showed particularly useful optical properties, such as the long-wavelength, sharp absorption and fluorescence, high fluorescence quantum yields (up to 0.91), and high photostability.
In their Full Paper on page 6476 ff., M. A. Petrukhina et al. describe for the first time the controlled addition of one and two electrons to a bowl-shaped corannulene and the isolation and structural characterization of the resulting product. The salts of corannulene mono- and dianions with sodium and potassium counterions have been investigated in the solid state and solution and the trends in the coordination preferences of alkali metals have been revealed.